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Results for "

gastrointestinal disorder

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adrenergic Receptor (2) Apical Sodium-Dependent Bile Acid Transporter (1) Autophagy (4) Bacterial (5) Biochemical Assay Reagents (2) Calcium Channel (1) Calmodulin (1) Cannabinoid Receptor (1) Cholecystokinin Receptor (2) Cytochrome P450 (1) Dopamine Receptor (2) Drug Metabolite (1) GSK-3 (1) Histamine Receptor (1) LRRK2 (1) mAChR (1) Monoamine Oxidase (1) Motilin Receptor (2) Neurokinin Receptor (1) Phospholipase (3) Potassium Channel (1) Proton Pump (4) RET (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (4) Endocrinology (1) Infection (6) Inflammation/Immunology (7) Metabolic Disease (15) Neurological Disease (6)

By Targets:

5-HT Receptor (3)

Adrenergic Receptor (2)

Apical Sodium-Dependent Bile Acid Transporter (1)

Autophagy (4)

Bacterial (5)

Biochemical Assay Reagents (2)

Calcium Channel (1)

Calmodulin (1)

Cannabinoid Receptor (1)

Cholecystokinin Receptor (2)

Cytochrome P450 (1)

Dopamine Receptor (2)

Drug Metabolite (1)

GSK-3 (1)

Histamine Receptor (1)

LRRK2 (1)

mAChR (1)

Monoamine Oxidase (1)

Motilin Receptor (2)

Neurokinin Receptor (1)

Phospholipase (3)

Potassium Channel (1)

Proton Pump (4)

RET (2)

By Research Areas:

Cancer (11)

Cardiovascular Disease (4)

Endocrinology (1)

Infection (6)

Inflammation/Immunology (7)

Metabolic Disease (15)

Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108283

Trepibutone AA 149; Supacal	Others	Inflammation/Immunology
Trepibutone (AA 149) increases secretion of bile and pancreatic juice, and accelerates flaccidity of the smooth muscle in the gastrointestinal tract. Trepibutone can be used for the research of cholecystitis and functional gastrointestinal disorders .

HY-145453

Propacetamol	Others	Inflammation/Immunology Cancer
Propacetamol is an analgesic agent. Propacetamol also is a precursor form of paracetamol. Propacetamol can be used in postoperative pain, acute trauma and gastrointestinal disorders .

HY-108292

Propacetamol hydrochloride	Others	Cancer
Propacetamol hydrochloride is an analgesic agent. Propacetamol hydrochloride also is a precursor form of paracetamol. Propacetamol hydrochloride can be used in postoperative pain, acute trauma and gastrointestinal disorders .

HY-147563

RET-IN-17	RET	Cancer
RET-IN-17 is a potent inhibitor of RET. RET-IN-17 has the potential for the research of pain associated with IBS and other gastrointestinal disorders and for the research of cancers with constitutive RET kinase activity (extracted from patent WO2016038552A1, compound 1) .

HY-B0189B

Mosapride citrate dihydrate TAK-370 citrate dihydrate; AS-4370 citrate dihydrate	5-HT Receptor Potassium Channel Cytochrome P450	Metabolic Disease
Mosapride (TAK-370) citrate dehydrate is a gastroprokinetic agent with 5-hydroxytryptamine₄ receptor agonist activity and has been widely used in the research of a variety of gastrointestinal disorders. Mosapride citrate dihydrate potently inhibits Kv4.3 in a concentration-dependent manner with IC₅₀ values of 15.2 μM . Mosapride citrate dihydrateselectively stimulates upper GI motility in vivo .

HY-147564

RET-IN-18	RET	Neurological Disease Cancer
RET-IN-18 is a pyridone compound. is a potent inhibitor of RET. RET-IN-18 is a potent inhibitor of RET. RET-IN-18 has the potential for the research of diseases related to irritable bowel syndrome (IBS) and other gastrointestinal disorders, as well as cancers, and neurodegenerative diseases (extracted from patent WO2022017524A1, compound 1) .

HY-40294

Indazole	Monoamine Oxidase GSK-3 LRRK2	Cardiovascular Disease Neurological Disease Cancer
Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases .

HY-U00382

Substance P Receptor Antagonist 1	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Substance P Receptor Antagonist 1 has the potential function in central nervous system disorders, respiratory, inflammatory diseases and gastrointestinal disorders.

HY-U00397

CB1 antagonist 1	Cannabinoid Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
CB1 antagonist 1 is an antagonist of CB1 receptor, used in the research of metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, gastrointestinal disorders, and cardiovascular conditions.

HY-U00375

Gastrin/CCK antagonist 1

Cholecystokinin Receptor Endocrinology

Gastrin/CCK antagonist 1 is an antagonist of gastrin/CCK, used for the research of gastrointestinal disorders.

Gastrin/CCK antagonist 1	Cholecystokinin Receptor	Endocrinology
Gastrin/CCK antagonist 1 is an antagonist of gastrin/CCK, used for the research of gastrointestinal disorders.

HY-B1613A

Clebopride malate 1 Publications Verification	Dopamine Receptor	Metabolic Disease
Clebopride malate is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders.

HY-144401

DS-3801b	Motilin Receptor	Metabolic Disease
DS-3801b is a potent and non-macrolide agonist of GPR38. DS-3801b is expected to be novel gastrointestinal prokinetic agents for the research of functional gastrointestinal disorders such as gastroparesis and chronic constipation .

HY-103146

GR125487 sulfamate	5-HT Receptor	Neurological Disease
GR125487 sulfamate is an orally active and selective antagonist of 5-HT₄R. GR125487 sulfamate effectively blocks the cognition enhancing effect. GR125487 sulfamate can be used to study memory disorders, gastrointestinal disorders, mood disorders and urinary tract dysfunction .

HY-U00415

Benzamide Derivative 1	Dopamine Receptor mAChR	Neurological Disease
Benzamide Derivative 1 is a benzamide derivative from patent EP0213775A1, compound 18. Benzamide Derivative 1 may be useful in treatment of gastrointestinal disorders.

HY-B1667

Isopropamide iodide
Isopropamide iodide is a long-acting quaternary anticholinergic agent. Isopropamide iodide is used in peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility .

HY-107642

MA-2029	Motilin Receptor	Metabolic Disease
MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC₅₀=4.9 nM). MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility .

HY-U00286

5-HT2A antagonist 1	5-HT Receptor	Cardiovascular Disease
5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. 5-HT2A antagonist 1 may be useful in treatment of gastrointestinal disorders circulatory disorders.

HY-B2175

Aspirin Aluminum Aluminum diacetylsalicylate	Others	Inflammation/Immunology
Aspirin Aluminum is a novel intermolecular compound which can inhibit gastrointestinal mucosal disorders induced by NSAIDs (non-steroidal anti-inflammatory agents) extracted from patent WO 2010064441 A1.

HY-148795

Ritivixibat	Apical Sodium-Dependent Bile Acid Transporter	Cardiovascular Disease Metabolic Disease
Ritivixibat is an inhibitor of ileal bile acid transporter (IBAT), as well as a bile acid modulator. Ritivixibat can be used for research of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases .

HY-N0584B

Anisodamine hydrochloride 6-Hydroxyhyoscyamine hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Anisodamine hydrochloride is an anticholinergic and α1 adrenergic receptor antagonist. Anisodamine hydrochloride can be used for improving blood flow in circulatory disorders such as septic shock, Anisodamine hydrochloride displays a spectrum of pharmacological effects similar to Atropine (HY-B1205) and Sopolamine (HY-B2065) including inhibition of salivation, gastrointestinal and sweat secretion, gastrointestinal motility, respiratory secretion and urinary bladder contraction in vivo .

HY-135111

4-Desmethoxy Omeprazole	Drug Metabolite	Infection Metabolic Disease Cancer
4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K_i of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .

HY-B0113S

Omeprazole-d₃ H 16868-d₃	Proton Pump Bacterial Autophagy	Infection Metabolic Disease Cancer
Omeprazole-d₃ is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].

HY-106301

Devazepide 1 Publications Verification L-364,718; MK-329	Cholecystokinin Receptor	Metabolic Disease
Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC₅₀s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders .

HY-W251598C

Sodium bicarbonate, for cell culture Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture	Biochemical Assay Reagents	Others
Sodium bicarbonate, for cell culture, an inorganic salt, is neutral to slightly alkaline. And it is susceptible to moisture and decomposition in the air. Sodium bicarbonate is widely used in food, pharmaceutical, cosmetics and other fields, the main uses include buffer, seasoning, disinfectant, pharmaceutical and proton gradient regulator. Sodium bicarbonate is also commonly used as an antacid to suppress gastrointestinal disorders, neutralize stomach acid and reduce stomach discomfort.

HY-B0113

Omeprazole 2 Publications Verification H 16868	Proton Pump Autophagy Bacterial Phospholipase	Infection Metabolic Disease Cancer
Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K_i of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .

HY-B0113A

Omeprazole sodium 2 Publications Verification H 16868 sodium
Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium shows competitive inhibition of CYP2C19 activity with a K_i of 2 to 6 μM . Omeprazole sodium also inhibits growth of Gram-positive and Gram-negative bacteria . Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .

HY-Y0756

Sodium bicarbonate Sodium hydrogen carbonate	Biochemical Assay Reagents	Others
Sodium bicarbonate, also known as baking soda, sodium bicarbonate, or sodium bicarbonate, is neutral to slightly alkaline. And it is susceptible to moisture and decomposition in the air. Sodium bicarbonate is widely used in food, pharmaceutical, cosmetics and other fields, the main uses include buffer, seasoning, disinfectant, pharmaceutical and proton gradient regulator. In the food industry, it is often used as a flour starter or leavening agent to make food swell up and become softer. Sodium bicarbonate is also commonly used as an antacid to suppress gastrointestinal disorders, neutralize stomach acid and reduce stomach discomfort.

HY-B0113S1

Omeprazole-d3-1 H 16868-d₃-1	Proton Pump Autophagy Bacterial Phospholipase	Infection Metabolic Disease Cancer
Omeprazole-d₃-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

HY-W153897

N-Methyltyramine	Adrenergic Receptor	Metabolic Disease
N-Methyltyramine is a protoalkaloid that can be isolated from various plant species. N-Methyltyramine is an α2-adrenoreceptor antagonist. N-Methyltyramine enhances appetite and digestion of foods by stimulating gastrin and pancreatic secretions. N-Methyltyramine can relax mouse small intestinal smooth muscle and inhibits small intestinal propulsion .

HY-B0113S3

Omeprazole-13CD3 H 16868-¹³C,d₃	Proton Pump Autophagy Bacterial Phospholipase	Infection Metabolic Disease Cancer
Omeprazole- ¹³C,d₃ is a ¹³C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

HY-P2797

Chitinase, serratia marcescens AMCase	Bacterial	Metabolic Disease Inflammation/Immunology
Chitinase (EC 3.2.1.14) has partial lysozyme activity and is widely found in bacteria, fungi, animals and some plants. Chitinase belongs to the glycosyl hydrolase family. Chitinase catalyzes chito-oligosaccharide hydrolysis. Chitinases also can serve as prognostic biomarkers of disease progression. Chitinase can be used in the research of pathogenesis of various human fibrotic and inflammatory disorders, particularly those of the lung (idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, sarcoidosis, and asthma) and the gastrointestinal tract (inflammatory bowel diseases (IBDs) and colon cancer) .

HY-N7503

Psoralenoside	Histamine Receptor Calcium Channel Calmodulin	Infection Metabolic Disease Cancer
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia . Psoralenoside exhibits high binding affinities against histaminergic H₁, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol) . Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

Anti-Obesity Compound Library	2338 compounds
Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries. MCE Anti-Obesity Compound Library owns a unique collection of 2338 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Sodium bicarbonate, for cell culture Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture	Buffer Reagents
Sodium bicarbonate, for cell culture, an inorganic salt, is neutral to slightly alkaline. And it is susceptible to moisture and decomposition in the air. Sodium bicarbonate is widely used in food, pharmaceutical, cosmetics and other fields, the main uses include buffer, seasoning, disinfectant, pharmaceutical and proton gradient regulator. Sodium bicarbonate is also commonly used as an antacid to suppress gastrointestinal disorders, neutralize stomach acid and reduce stomach discomfort.

Sodium bicarbonate Sodium hydrogen carbonate	Biochemical Assay Reagents
Sodium bicarbonate, also known as baking soda, sodium bicarbonate, or sodium bicarbonate, is neutral to slightly alkaline. And it is susceptible to moisture and decomposition in the air. Sodium bicarbonate is widely used in food, pharmaceutical, cosmetics and other fields, the main uses include buffer, seasoning, disinfectant, pharmaceutical and proton gradient regulator. In the food industry, it is often used as a flour starter or leavening agent to make food swell up and become softer. Sodium bicarbonate is also commonly used as an antacid to suppress gastrointestinal disorders, neutralize stomach acid and reduce stomach discomfort.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7503

Psoralenoside	Infection Structural Classification Classification of Application Fields Simple Phenylpropanols Leguminosae Source classification Metabolic Disease Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields	Histamine Receptor Calcium Channel Calmodulin
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia . Psoralenoside exhibits high binding affinities against histaminergic H₁, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol) . Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-N0584B

Anisodamine hydrochloride 6-Hydroxyhyoscyamine hydrochloride	Structural Classification Alkaloids Pyrrole Alkaloids Anisodus tanguticus (Maxinowicz) Pascher Source classification Plants Solanaceae	Adrenergic Receptor
Anisodamine hydrochloride is an anticholinergic and α1 adrenergic receptor antagonist. Anisodamine hydrochloride can be used for improving blood flow in circulatory disorders such as septic shock, Anisodamine hydrochloride displays a spectrum of pharmacological effects similar to Atropine (HY-B1205) and Sopolamine (HY-B2065) including inhibition of salivation, gastrointestinal and sweat secretion, gastrointestinal motility, respiratory secretion and urinary bladder contraction in vivo .

HY-W153897

N-Methyltyramine	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Leguminosae Other Alkaloids Source classification Acacia auriculiformis A.Cunn. ex Benth Plants Endogenous metabolite	Adrenergic Receptor
N-Methyltyramine is a protoalkaloid that can be isolated from various plant species. N-Methyltyramine is an α2-adrenoreceptor antagonist. N-Methyltyramine enhances appetite and digestion of foods by stimulating gastrin and pancreatic secretions. N-Methyltyramine can relax mouse small intestinal smooth muscle and inhibits small intestinal propulsion .

Cat. No.	Product Name	Chemical Structure

HY-B0113S

Omeprazole-d₃
Omeprazole-d₃ is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].

HY-B0113S1

Omeprazole-d3-1
Omeprazole-d₃-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

Omeprazole-d3-1

Omeprazole-d₃-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

HY-B0113S3

Omeprazole-13CD3
Omeprazole- ¹³C,d₃ is a ¹³C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

Omeprazole-13CD3

Omeprazole- ¹³C,d₃ is a ¹³C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

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